Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana

Abstract Gordonia sp. are members of the actinomycete family, their contribution to environment improvement and environmental protection by biological degradation ability, but there few studies on antimicrobial activity secondary metabolites. Our team isolated purified an WA 4-31 from intestinal tract Periplaneta americana , firstly identified strain morphological characteristics phylogenetic analyses, found it was completely homologous terrae Indian desert. Meanwhile, actinomycin D ( 1 ), X2 2 mojavensin A 3 ) cyclic (leucine-leucne) dipeptide 4 were obtained EtOAc extract broth 4-31. Compounds – showed anti-fungus activities against Candida albicans Aspergillus niger A. fumigatus Trichophyton rubrum also anti-MRSA inhibited Escherichia coli in different degree. Interestingly, we when mixed with ratio 1:1, mixture anti- better than single. Besides, compounds 1–3 had varying degrees antiproliferative CNE-2 HepG-2 cell lines. These indicated that rare possessed a potential as source active